Evidence mapPaperPMID 41792160Full record

ArticleNPJ microgravity2026

Human plasma extracellular vesicles as an exercise mimetic to preserve skeletal muscle plasticity during disuse.

Alexander M Fliflet, Yanqi Tan, Takeshi M Barnes, Ane Nishitha Vijayan, Sung Jun Choi, Max T Deutz, Zan Zupancic, Ray A Spradlin, Benjamin F Miller, Nicholas A Burd and 2 more

Abstract read
In one paragraph

Article in NPJ microgravity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander M FlifletDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Yanqi TanDepartment of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Takeshi M BarnesDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Ane Nishitha VijayanBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Sung Jun ChoiDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Max T DeutzDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Zan ZupancicDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Ray A SpradlinBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Benjamin F MillerAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Nicholas A BurdDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Jonathan V SweedlerBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Marni D BoppartDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL, USA. mboppart@illinois.edu.

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · 2004 to 2025
$3.2M
NASA-TRISH, NIH, Beckman Institute NNX16AO69A, NIH P30 DA018310NIDA NIH HHS P30 DA018310
6 · The paper itself

Abstract

The purpose of this study was to determine the extent to which extracellular vesicles (EVs) circulating in blood after exercise training act as an effective mimetic to maintain skeletal muscle mass during unloading and/or accelerate recovery after disuse. Ten healthy males (27.7 ± 7.1 y) were recruited for a 6-week progressive resistance and endurance training program. EVs were isolated from blood before (EVs) or immediately after training (ExerVs). EVs were intraperitoneally injected into male mice (4×; 3 × 10

Identifiers

PMID41792160
PMCPMC13230526

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.