Evidence mapPaperPMID 41793648Full record

ReviewCardiovascular drugs and therapy2026

Therapeutic Ultrasound in Cardiovascular Medicine: Applications of Low-intensity Pulsed Ultrasound and Ultrasound-targeted Microbubble Destruction.

Yucong Shi, Yongqing Ye, Shanshan Chang, Dongxu Lu, Yinzhu Chu

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In one paragraph

Review in Cardiovascular drugs and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yucong ShiDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Yongqing YeThe First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Shanshan ChangDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Dongxu LuThe First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Yinzhu ChuDepartment of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. yinzhuchu196911@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) represents a significant global health challenge, with its high incidence and mortality rates placing a substantial burden on both patients and society. Although conventional therapies have achieved certain results, they continue to face considerable limitations. In recent years, therapeutic ultrasound has emerged as a promising medical technology, offering notable potential in the treatment of CVD owing to its non-invasiveness, safety, and targeting precision. Low-intensity pulsed ultrasound (LIPUS), a form of therapeutic ultrasound, uses pulsed, low-intensity, moderate-frequency acoustic waves to produce biological effects. This modality minimizes thermal impact while enhancing mechanical interactions. Another well-regarded technique is ultrasound-targeted microbubble destruction (UTMD), an innovative gene delivery system characterized by safety, reliable targeting, and high personalization. In clinical practice for CVD, both LIPUS and UTMD exhibit distinct advantages. This review examines the current landscape of CVD and discusses the potential and future applications of LIPUS and UTMD in their management.

Indexed as

Cardiovascular diseaseNon-invasive treatmentTargeted therapyTherapeutic ultrasound

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.