Evidence map›Paper›PMID 41793756›Full record

ReviewBrain : a journal of neurology2026

Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.

Albert Joseph, Rick A Adams, Fiona Gaughran, Oliver D Howes, Davide Martino, Francesca Morgante, Mark J Edwards

Abstract readReview
In one paragraph

Review in Brain : a journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Albert JosephInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE5 8AF, UK.ORCID 0000-0002-0956-8167
Rick A AdamsCentre for Medical Image Computing, Department of Computer Science, University College London, London WC1V 6LG, UK.ORCID 0000-0002-7661-8881
Fiona GaughranInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE5 8AF, UK.
Oliver D HowesInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE5 8AF, UK.
Davide MartinoDepartment of Clinical Neurosciences and Hotchkiss Brain Unit, University of Calgary, Calgary T2N 1N4, Canada.
Francesca MorganteNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, City St George's University of London, London EC1V 0HB, UK.ORCID 0000-0002-9834-3639
Mark J EdwardsInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London SE5 8AF, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a common and often disabling neuropsychiatric condition. Whilst sensorimotor abnormalities such as dyskinesia, parkinsonism and motor incoordination are prevalent in schizophrenia, they are often attributed to medication side effects or classified as neurological soft signs or catatonic phenomena. Here, we outline the prevalence, characteristics and challenges in accurate phenotyping of sensorimotor disturbances in schizophrenia, including amongst medication-naïve individuals, demonstrating that sensorimotor dysfunction may be an integral manifestation of the disease process. We then review how current understanding regarding the pathogenesis of schizophrenia supports this possibility and consider how better characterization of sensorimotor dysfunction may improve management and the development of novel treatments for schizophrenia, playing particular attention to the role of instrumental sensorimotor assessment.

Indexed as

Movement DisordersSchizophreniaHumansmovement disordersneuropsychiatryparkinsonismpsychosisschizophreniatardive dyskinesia

Identifiers

PMID41793756
PMCPMC13337243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.