Evidence map›Paper›PMID 41794348›Full record

ArticleInternational journal of pharmaceutics2026

Intranasal hybrid nanoparticles encapsulating rizatriptan enhance antimigraine efficacy in an optogenetic spreading depression model.

Melih Z Kaya, Yakup Gultekin, Mustafa Celebier, Murat Soyseven, Imran Vural, Levent Oner, Cenk Ayata, Sibel Bozdag Pehlivan, Andrea M Harriott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melih Z KayaNeurovascular Research Unit, Massachusetts General Hospital, Boston, MA, USA; Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Yakup GultekinDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Mustafa CelebierDepartment of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Murat SoysevenAnadolu University, Yunus Emre SHMYO, Department of Analytical Chemistry, Eskisehir, Turkey.
Imran VuralDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Levent OnerDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Cenk AyataNeurovascular Research Unit, Massachusetts General Hospital, Boston, MA, USA.
Sibel Bozdag PehlivanDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. Electronic address: sbozdag@hacettepe.edu.tr.
Andrea M HarriottNeurovascular Research Unit, Massachusetts General Hospital, Boston, MA, USA.

Funding

Sex Differences in the Role of Gonadal Hormones and the Hypothalamus in Migraine with Aura.K08NS124991 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Andrea M Harriott · 2022 to 2026
$1.1M
NINDS NIH HHS K08 NS124991
6 · The paper itself

Abstract

Cortical spreading depression (SD) is the likely cause of migraine aura and a putative headache trigger. Migraine treatments, including triptans and calcitonin gene related peptide (CGRP) receptor antagonists, are limited by poor bioavailability. This study evaluates whether intranasally administered poly lactic co-glycolic acid (PLGA) based hybrid nanoparticles (HNPs) encapsulating rizatriptan (RZT) could provide sustained drug release, enhance brain delivery, and improve therapeutic efficacy against periorbital allodynia triggered by optogenetic SD in mice. CGRP

Indexed as

Cortical Spreading DepressionMigraine DisordersNanoparticlesTryptaminesAdministration, IntranasalAnimalsBrainCalcitonin Gene-Related PeptideDelayed-Action PreparationsDisease Models, AnimalDrug LiberationHyperalgesiaMaleMiceMice, Inbred C57BLPolylactic Acid-Polyglycolic Acid CopolymerCalcitonin Gene-Related PeptideDelayed-Action PreparationsPolylactic Acid-Polyglycolic Acid CopolymerrizatriptanTriazolesTryptaminesCGRP(8-37)Hybrid nanoparticleMigraineOptogenetic cortical spreading depressionPeriorbital allodyniaRizatriptan

Identifiers

PMID41794348
PMCPMC13174935

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.