ArticleBMC neurology2026
Body weight-related alterations in white matter functional connectivity in children: An fMRI study.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChildhood obesity is linked to altered brain functional connectivity (FC) in brain gray matter (GM), with potential implications on changes in cognition function. This study investigates white matter – white matter (WM-WM) and WM-GM FC differences between children with normal-weight (NW) and overweight/obese (OW/OB) using functional Magnetic Resonance Imaging (fMRI).
methodsResting-state fMRI data from 68 children aged 10–12 years (32 OW/OB, 36 NW) were analyzed. FC matrices were constructed using predefined WM and GM region of Interest (ROI). Group differences and correlations with body mass index (BMI) were analyzed using t-test and Pearson correlation.
resultsThe OW/OB group exhibited increased WM-WM FC between the middle cerebellar peduncle (m.CBLP) and right uncinate fasciculus (r.UF), which was also positively correlated with BMI (R = 0.47, p = 0.0001). Meanwhile, reduced WM-GM FC was observed between the body of the corpus callosum (b.CC) and right dorsolateral prefrontal cortex (r.DLPFC), which was also negatively correlated with BMI (R = -0.44, p = 0.0002).
conclusionsOur findings suggest that childhood obesity is associated with changes in WM-WM and WM-GM FC, potentially impacting motor coordination (via m.CBLP-r.UF) and executive function (via b.CC-r.DLPFC), contributing to cognitive regulation differences.
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