Observational studyBMC anesthesiology2026
The predictive value of tidal volume challenge-induced hemodynamic changes for fluid responsiveness in patients undergoing thoracoscopic surgery with one-lung ventilation: a prospective observational study.
Observational study in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundVideo-assisted thoracic surgery (VATS) relies on one-lung ventilation (OLV) to achieve optimal surgical conditions. However, the lung protective ventilation strategies commonly employed during OLV diminish the accuracy of traditional dynamic parameters in predicting fluid responsiveness. The tidal volume challenge (TVC) has been proposed to overcome this limitation, yet its effectiveness in OLV patients remains to be validated. In this study, we used LiDCO to evaluate TVC-induced changes in SVV(ΔSVV_TVC) and PPV(ΔPPV_TVC), and assessed their ability to predict fluid responsiveness in patients receiving lung-protective OLV during VATS.
methodsAll patients received OLV in lateral position after general anesthesia induction. Upon achieving hemodynamic stability, the study protocol was initiated. Hemodynamic and respiratory parameters, including heart rate, mean arterial pressure, stroke volume variation (SVV), pulse pressure variation (PPV), stroke volume index (SVI), cardiac index, peak inspiratory pressure, and dynamic lung compliance were recorded at four time points: before TVC (T
resultsAmong the 60 patients, 26 (43%) were fluid responders. ROC analysis showed that the area under the curve (AUC) of ΔSVV_TVC for predicting fluid responsiveness was 0.83 (95% CI, 0.71-0.91), with an optimal cutoff value of > 2%, sensitivity of 77%, specificity of 76%, and a gray zone range of 1%-3% encompassing 23 patients (38%). For ΔPPV_TVC, the AUC was 0.86 (95% CI, 0.74-0.93), with a cutoff of > 3%, sensitivity of 85%, specificity of 80%, and a gray zone of 2%-4% including 13 patients (22%).Subgroup analysis revealed no significant difference in the predictive AUC values of ΔSVV_TVC or ΔPPV_TVC between the left and right lateral decubitus positions.
conclusionTidal volume challenge -induced changes in SVV and PPV effectively predict fluid responsiveness in OLV patients, and their predictive performance is not influenced by patient position.
trial registrationThis trial was registered with Chinese Clinical Trial Registry, ChiCTR2300075285, August 31, 2023.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.