Observational studyCritical care (London, England)2026
Adverse events as key risk factors for in-hospital mortality in intensive care units.
Observational study in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
introductionIntensive care units (ICUs) represent high-risk environments for adverse events (AEs). Preventing these events requires a solid understanding of their epidemiology based on standardized and validated methodologies. The aim of this study was to quantify AEs using the established Harvard Medical Practice Study (HMPS) methodology, identify associated factors, and analyze their prognostic impact on critically ill patients. MATERIALS AND
methodsA multicenter observational study with a cross-sectional design was conducted in 26 hospitals across the Community of Madrid on a single, specified day in May 2019. Following the HMPS methodology and using its standardized instruments, clinical records were reviewed in two phases: (1) an AE screening phase and (2) a confirmation and characterization phase for cases with positive screenings. A multivariate logistic regression model was developed to identify variables associated with the presence of AEs, and the association between AEs and in-hospital mortality was assessed using an explanatory model adjusted for potential confounders.
resultsA total of 458 patients were included, of whom 125 (27.3%; 95% CI: 23.4 to 31.6) had ≥1 AE. The following antecedents were associated with the presence of AEs: pressure ulcer (PU), hypoalbuminemia, mechanical ventilation, central venous catheter, surgical intervention and sensory deficit. Among the AEs found, 44.6% were health care-associated infections (HAIs). In-hospital mortality among patients with AEs was twice that observed in patients without AEs (OR: 2.15; 95% CI: 1.10–4.25).
conclusionsThe presence of AEs was associated with a two-fold higher risk of in-hospital mortality. Among the identified AEs, HAIs were the most frequent and had the highest mortality. Designing and implementing bundles of measures adapted to the individual risk of presenting AEs in the ICU emerges as the next step in the development of strategies to reduce the prevalence of AEs.
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