ArticleCommunications medicine2026
Modelling donor factors influencing pancreas transplant utilization and evolution of decision-making over time.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Expanding the Pancreas Donor Pool: Reassessing the Impact of Donor Body Mass Index on Transplant Outcomes.Clinical transplantation · 2026Article
- Time to Death and Donation After Circulatory Death Kidney Transplant Outcomes: Opportunities for Improved Utilization in the United States.Clinical transplantation · 2026Article
- Potential for donation after circulatory death in Germany: a multicenter retrospective study at seven university hospitals.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundPancreas transplantation remains the only definitive treatment for diabetes mellitus. However, the global number of pancreas transplants and utilisation of pancreas grafts is declining. We aimed to identify significant donor factors associated with pancreas non-use.
methodsPopulation-cohort study using United States (US) data from the Organ Procurement and Transplant Network (OPTN) registry (2010-2024). Multivariable regression models were constructed to assess associations between donor characteristics and pancreas utilisation. Restricted cubic splines were used to preserve non-linear relationships and interaction terms with donation date were performed, to capture evolving decision-making behaviours.
resultsWe identify 23 donor factors significantly associated with utilisation (n = 14,612 transplants from 133,986 donors). The most important continuous donor factors are age, BMI and peak creatinine; all showing significant non-linear relationships with utilisation (all P < 0.001). Donor type is the most important categorical variable, with donation after circulatory death (DCD) having 92% lower odds of utilisation (aOR=0.078, 95% CI = 0.070 to 0.087, P = < 0.001). Interaction analyses reveal increasing reluctance to use DCD donors or older donors over the study period (both interaction P < 0.001). Conversely, clinicians have become more comfortable transplanting pancreases from Hepatitis C positive donors and IV drug use (IVDU) donors over time (both interaction P < 0.001).
conclusionsThis large population cohort study demonstrates significant shifts in utilisation decision-making over time. Growing reluctance to use DCD, despite evidence of favourable outcomes, highlights a valuable area to focus US pancreas utilisation efforts. Meanwhile, previously underused groups such as Hepatitis C positive and IVDU donors show growing acceptance, supporting expansion of these donor populations globally.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.