Evidence map›Paper›PMID 41795427›Full record

ReviewCell stem cell2026

Adult neurogenesis: New neurons, new opportunities.

Birte Doludda, Warsha Barde, Francesco D'Egidio, Carlos P Fitzsimons, Jonas Frisén, Fred H Gage, Sebastian Jessberger, Orly Lazarov, D Chichung Lie, Paul J Lucassen and 7 more

Abstract readReview
In one paragraph

Review in Cell stem cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Birte DoluddaGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD-Center for Regenerative Therapies, TU Dresden, Dresden, Germany.
Warsha BardeGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD-Center for Regenerative Therapies, TU Dresden, Dresden, Germany.
Francesco D'EgidioUniversity of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy.
Carlos P FitzsimonsBrain Plasticity Department, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands.
Jonas FrisénDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Fred H GageLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Sebastian JessbergerLaboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, Zurich, Switzerland.
Orly LazarovUniversity of Illinois Chicago College of Medicine, Chicago, IL, USA.
D Chichung LieFriedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Paul J LucassenSwammerdam Institute for Life Sciences, University of Amsterdam Brain Plasticity Group, Amsterdam, the Netherlands.
Chiara de LuciaBasic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Evgenia SaltaNetherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Hongjun SongDepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; The Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Juan SongUniversity of North Carolina at Chapel Hill, Department of Pharmacology, 120 Mason Farm Road, Chapel Hill, NC, USA.
Sandrine ThuretBasic & Clinical Neuroscience Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Tomohisa TodaGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany; Max-Planck-Zentrum für Physik und Medizin Laboratory of Neural Epigenomics, Erlangen, Germany.
Gerd KempermannGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD-Center for Regenerative Therapies, TU Dresden, Dresden, Germany. Electronic address: gerd.kempermann@dzne.de.

Funding

Continuous Neurogenesis in the Mammalian HippocampusR35NS116843 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HONGJUN SONG · 2020 to 2026
$6.9M
The role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?sR01AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2009 to 2026
$5.6M
Hippocampal neurogenesis in cognitive function and dysfunction in Alzheimer's disease.R01AG076940 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2022 to 2026
$3.7M
Plasticity circuits in Alzheimer s diseaseRF1AG033570 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2020 to 2021
$2.9M
Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal functionR01MH122692 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2020 to 2024
$2.9M
Mechanisms underlying sporadic Alzheimer's diseaseR01AG060238 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2018 to 2022
$2.4M
Role of Cholecystokinin in the Dentate GyrusR01NS121300 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2025
$2.3M
Regulation and functional contribution of hypothalamic modified adult hippocampal neurogenesisR01MH132222 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.3M
Training program in the biology and translational research on Alzheimer's diseaseand related dementiasT32AG057468 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Stephanie M Cologna, Orly Lazarov · 2017 to 2026
$2.3M
Enhancing adult-born neurons to restore brain functions in Alzheimer's diseaseR01AG084207 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.1M
The role of APP in neurogenesis and AD in Down syndromeRF1AG079002 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAZAROV, ORLY · 2022 to 2022
$2.0M
The role of APP in neurogenesis and AD in Down syndromeR01AG079002 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Orly Lazarov · 2025 to 2026
$1.3M
NIA NIH HHS R01 AG033570NIA NIH HHS R01 AG060238NIA NIH HHS R01 AG071000NIA NIH HHS R01 AG076940NIA NIH HHS R01 AG079002NIA NIH HHS R01 AG084207NIA NIH HHS RF1 AG033570NIA NIH HHS RF1 AG079002NIA NIH HHS T32 AG057468NIMH NIH HHS R01 MH122692NIMH NIH HHS R01 MH132222NINDS NIH HHS R01 NS121300NINDS NIH HHS R35 NS116843
6 · The paper itself

Abstract

The 38 currently registered clinical trials with the keyword "adult neurogenesis" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.

Indexed as

NeurogenesisNeuronsAnimalsHippocampusHumansNeural Stem Cellshippocampuslearningneural networksplasticitystem cells

Identifiers

PMID41795427
PMCPMC13157704

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.