ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Hippocampal subfield thickness and shape analysis in examining the impact of TDP-43 in primary age-related tauopathy.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionHippocampal subfields are vulnerable to the transactive response DNA-binding protein of 43 kDa (TDP-43) and tau in primary age-related tauopathy (PART). Geometry-based morphometric analysis can improve the detection of structural changes in the hippocampus.
methodsForty-seven cases of autopsy-confirmed PART without TDP-43 and 19 cases of PART with TDP-43 underwent antemortem magnetic resonance imaging (MRI) hippocampal segmentation and shape analysis. A separate cohort of 16 younger healthy individuals (YHIs) was included as a reference group. Hippocampal shape was analyzed in Python with non-parametric cluster permutation testing.
resultsPART(TDP+) group exhibited thinner left subiculum and CA1, with curvature deformations in left CA1 and CA2/3, relative to PART(TDP-). Both PART groups showed right-sided predominance of thinning in presubiculum and subiculum, as well as curvature deformations in right presubiculum, subiculum, and CA1 when compared to YHIs. DISCUSSION: Geometry-based analysis showed different patterns of hippocampal thinning and curvature associated with PART(TDP+) compared to PART(TDP-).
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