ArticleThe Journal of international medical research2026
Clinical characterization of 39 patients with autoimmune pulmonary alveolar proteinosis.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectivesWe aimed to explore the clinical manifestations, examination findings, diagnostic methods, and treatment efficacy of patients with pulmonary alveolar proteinosis and improve clinicians' understanding of this disease.MethodsWe retrospectively analyzed the clinical characteristics of 39 patients diagnosed with autoimmune pulmonary alveolar proteinosis admitted to Fuzhou Pulmonary Hospital, Fujian Province, from August 2013 to December 2024. We also analyzed the correlations between lactate dehydrogenase, arterial partial oxygen pressure, and pulmonary alveolar arterial oxygen differential pressure, lung function, tumor markers, blood lipids, and disease severity. Furthermore, the relevant literature was reviewed.ResultsOf the 39 patients, 23 were male, 16 were female, 18 were smokers, and 11 had pneumoconiosis. The main clinical symptoms were cough and shortness of breath. The typical manifestations of chest computed tomography were "map-like" changes or "crazy-paving pattern". The main manifestations of pulmonary function were diffusion dysfunction and restricted ventilation dysfunction. pulmonary alveolar proteinosis disease severity score was positively correlated with lactate dehydrogenase, pulmonary alveolar arterial oxygen differential pressure and the tumor markers carcinoembryonic antigen, cytokeratin 19 fragment antigen 21-1, neuron specific enolase, and carbohydrate antigen 153 (
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