Evidence map›Paper›PMID 41796133›Full record

ArticleNature communications2026

p38 MAPK orchestrates cross-tissue potassium homeostasis for survival.

Rong Huang, Fangchao Hu, Yiyao Li, Qifei Gao, Jintao Huang, Jiarui Wang, Wei Lu, Liping Wang, Yapeng Fang, T Keith Blackwell and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rong Huang *Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Fangchao Hu *Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0009-0005-3921-7420
Yiyao Li *Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Qifei GaoDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0001-7751-7671
Jintao HuangDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Jiarui WangDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Wei LuDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0003-2031-9513
Liping WangDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0003-1049-6049
Yapeng FangDepartment of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
T Keith BlackwellResearch Division, Joslin Diabetes Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3763-9134
Ziyun Wu *Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. wuziyun@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-8239-1890

Funding

Signaling mechanisms that detect stress and maintain homeostasis - Research Supplement to Promote Diversity in Health-Related ResearchR35GM122610 · NIGMS · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2017 to 2025
$4.7M
Uncovering Conserved Lipid Homeostasis Mechanisms that Mediate Longevity after Germ Cell Loss in C. ElegansR01AG054215 · NIA · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 2017 to 2026
$3.9M
National Natural Science Foundation of China (National Science Foundation of China) 82171550National Natural Science Foundation of China (National Science Foundation of China) U23A20258NIA NIH HHS R01 AG054215NIGMS NIH HHS R35 GM122610
6 · The paper itself

Abstract

Potassium is vital for life, yet how potassium homeostasis is maintained at the tissue or organismal level under dietary scarcity remains poorly understood. Stress-activated signaling pathway p38 MAPK is implicated in immune response and aging, but its specific role in low potassium response is unclear. Here we show that a specific p38 MAPK-ATF-7 pathway orchestrates cross-tissue potassium homeostasis in Caenorhabditis elegans. It drives transcriptional upregulation of a crucial P-type ATPase pump CATP-3 specifically in the hypodermis, a process that integrates cell-autonomous mechanisms with non-autonomous ASI neuronal signals, thereby enhancing organismal survival during potassium deficiency. Notably, this regulation is distinct from canonical osmotic stress responses, revealing a specialized and conserved survival strategy. Analogous p38-mediated control of P-type ATPases occurs in yeast and mammalian cells, suggesting broad relevance. Our findings redefine potassium regulation as a cross-tissue process linked to lifespan, stress signaling, and innate immunity with potential implications for aging and age-related diseases.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsHomeostasisp38 Mitogen-Activated Protein KinasesPotassiumAdenosine TriphosphatasesAnimalsImmunity, InnateSignal TransductionAdenosine TriphosphatasesCaenorhabditis elegans Proteinsp38 Mitogen-Activated Protein KinasesPotassium

Identifiers

PMID41796133
PMCPMC13100137

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.