Evidence map›Paper›PMID 41796245›Full record

ArticleScientific reports2026

Differentiation of psychotic and affective disorder patients from healthy controls using the niacin skin flush test: a novel analytical method and the SKINREMS system-preliminary research.

Ryszard Sitarz, Joanna Rog, Robert Karpiński, Anna Machrowska, Kaja Karakuła, Jacek Bogucki, Dariusz Juchnowicz, Anna Rymuszka, Anna Sierosławska, Hanna Karakuła-Juchnowicz

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ryszard Sitarz1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, Gluska Street 1, 20-439, Lublin, Poland. ryszard.sitarz@umlub.edu.pl.
Joanna RogDepartment of Basic Medical Sciences, The John Paul II Catholic University of Lublin, Lublin, Poland.
Robert Karpiński1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, Gluska Street 1, 20-439, Lublin, Poland.
Anna MachrowskaDepartment of Machine Design and Mechatronics, Faculty of Mechanical Engineering, Lublin University of Technology, Nadbystrzycka 36, 20-618, Lublin, Poland.
Kaja KarakułaDepartment of Clinical Neuropsychiatry, Faculty of Medicine, Medical University of Lublin, Gluska Street 1, 20-439, Lublin, Poland.
Jacek BoguckiJohn Paul II Catholic University of Lublin, Faculty of Medicine, Lublin, Poland.
Dariusz JuchnowiczDepartment of Psychiatry and Psychiatric Nursing, Medical University of Lublin, Lublin, Poland.
Anna RymuszkaDepartment of Animal Physiology and Toxicology, Faculty of Medicine, The John Paul II Catholic University of Lublin, Lublin, Poland.
Anna SierosławskaDepartment of Animal Physiology and Toxicology, Faculty of Medicine, The John Paul II Catholic University of Lublin, Lublin, Poland.
Hanna Karakuła-Juchnowicz1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, Gluska Street 1, 20-439, Lublin, Poland.

Funding

Rector of the Medical University of Lublin GW/PB/6/2022
6 · The paper itself

Abstract

According to the phospholipid membrane theory of psychotic disorders, fatty acid metabolism may play a role in the etiopathogenesis of schizophrenia (SCH) and related disorders. Weakened skin reactions to niacin have been documented in SCH and bipolar disorder (BD), prompting research into biomarkers underlying these responses. So far, there is also no standard for performing and interpreting the niacin skin flush test (NSFT) which creates an opportunity for development in this area. The NSFT was conducted based on the SKINREMS system and an original method of analyzing measurements. 120 individuals including 33 patients diagnosed with first-episode psychosis (FEP), 22 with BD, 13 with schizoaffective disorder (SA), 13 with chronic schizophrenia (CS), and 39 healthy controls (HC) participated in the study. NSFT differentiated patients from HC and among subgroups of patients based on color saturation, specific time points, and niacin solution concentrations. The NSFT is a fast, effective, and cheap method that allows the differentiation of individuals suffering from psychotic disorders from HC. Standardization of the test method may contribute to more precise searches for biomarkers responsible of responses in the NSFT and can support the diagnostic process. The presented study is preliminary and exploratory in nature. Developing a method of using NSFT may contribute to a more precise search for biomarkers responsible for the results and thus to the diagnostic process.

Indexed as

Bipolar DisorderMood DisordersNiacinPsychotic DisordersSkin TestsAdultBiomarkersCase-Control StudiesDiagnosis, DifferentialFemaleFlushingHumansMaleMiddle AgedSchizophreniaYoung AdultBiomarkersNiacinBiomarkersBipolar affective disorderFatty acids metabolismNiacin testPsychosisSchizoaffective disorderSchizophrenia

Identifiers

PMID41796245
PMCPMC12988173

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.