Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
The effect of reminder mobile application use on medication adherence after total thyroidectomy: a randomized controlled trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05503576 (Effect of Mobile Application Usage on Drug Compliance After Thyroidectomy), which is not on this map. Not yet cited in PubMed.
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Effect of Mobile Application Usage on Drug Compliance After Thyroidectomy
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2 authors.
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Abstract
purposeThis study aimed to investigate the effect of using a reminder-based mobile application on medication adherence in patients who underwent total thyroidectomy. MATERIALS AND
methodsThis randomized controlled trial followed CONSORT guidelines and included 63 patients who underwent total thyroidectomy at a university and a state hospital. The intervention group (n = 31) used a reminder mobile application for 8 weeks, while the control group (n = 32) received standard care. Data were collected at weeks 1, 4, and 8 using a personal information form, follow-up form, and Morisky eight-item medication adherence scale. Statistical analyses included chi-square, t-test, ANOVA, Mann-Whitney U, and Friedman tests.
resultsAt week 4, the intervention group demonstrated significantly higher mean MMAS-8 scores compared to the control group (6.58 vs. 5.71, p = 0.016). Furthermore, at week 8, a statistically significant difference was observed between groups in terms of medication adherence levels based on MMAS-8 cutoff categories (χ DISCUSSION: This study showed that a reminder-based mobile application effectively improved medication adherence in patients after total thyroidectomy. Increased adherence was observed in the intervention group, while a decline occurred in the control group. These findings indicate that reminder-based mobile health interventions may support medication adherence during the early postoperative period.
conclusionReminder mobile applications can positively impact medication adherence. Integrating such tools into routine postoperative follow-up may support treatment continuity in patients receiving levothyroxine after total thyroidectomy. CLINICALTRIALS: GOV IDENTIFIER: NCT05503576, registration date 08 December 2022.
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