Evidence map›Paper›PMID 41796687›Full record

ArticleJournal of medicinal chemistry2026

Tunable Aromatic Sulfoxides and Sulfones as Cysteine-Targeting Warheads: Exploring the Structure-Reactivity Relationship.

Hampus Nyström, Anna P Valaka, Hanna A Kalesse, Liliana Håversen, Thomas Olsson, Anders Gunnarsson, Fritz Schweikart, Jan Borén, Morten Grøtli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hampus NyströmDepartment of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0009-0006-8139-3839
Anna P ValakaDepartment of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.
Hanna A KalesseDepartment of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.
Liliana HåversenDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
Thomas OlssonDepartment of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.
Anders GunnarssonDiscovery Sciences, R&D Gothenburg, AstraZeneca, 431 83 Mölndal, Sweden.
Fritz SchweikartPharmaceutical Sciences, Mass Spectrometry/Structural Elucidation, R&D Gothenburg, AstraZeneca, 431 83 Mölndal, Sweden.ORCID 0000-0002-2201-7896
Jan BorénDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
Morten GrøtliDepartment of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0003-3621-4222

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Covalent modalities are powerful tools in medicinal chemistry and chemical biology, enabling selective protein inhibition and functional labeling through precise tuning of warhead reactivity. We report the design and synthesis of a 48-member library of aromatic sulfoxide and sulfone warheads capable of nucleophilic aromatic substitution (S

Indexed as

CysteineProtein Kinase InhibitorsSulfonesSulfoxidesAdenineAgammaglobulinaemia Tyrosine KinaseHumansMolecular Dynamics SimulationPiperidinesStructure-Activity RelationshipAdenineAgammaglobulinaemia Tyrosine KinaseBTK protein, humanCysteineibrutinibPiperidinesProtein Kinase InhibitorsSulfonesSulfoxides

Identifiers

PMID41796687
PMCPMC13036770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.