ArticleJournal of neurochemistry2026
Dysregulated Plasticity in Serotonin, Galanin, and Opioid Systems Contributes to Limbic Seizure Recruitment in Wistar Audiogenic Rat.
Article in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The Wistar Audiogenic Rat (WAR) strain is a genetically selected model of reflex epilepsy, susceptible to mesencephalic and, following chronic stimulation, limbic seizures. In this study, we examined the molecular underpinnings of this seizure progression by assessing gene expression profiles of pre-synaptic serotonergic components in Dorsal Raphe Nucleus (DRN) and post-synaptic receptors in the Basolateral Amygdala (BLA), Central Amygdala (CeA), and Hippocampus (HIP). Concurrently, we evaluated mRNA expression of Galanin (Gal) and Prodynorphin (Pdyn) in the Supraoptic Nucleus (SON) and their respective receptors in the BLA, CeA, and HIP. WARs and control Wistar rats underwent a ten-day audiogenic kindling (AK) protocol, involving twice-daily exposure to a high-intensity acoustic stimulus to induce seizures. WARs were sub-grouped based on their behavioral phenotype (seizure scales) into limbic-recruited seizures (LiR) and non-limbic-recruited (n-LiR). Quantitative PCR analysis of brain micropunches revealed a significant failure of adaptive plasticity in WARs. Unlike control rats, which showed a robust upregulation of serotonergic (5-HT-ergic) components in the DRN in response to the chronic stress of the kindling protocol, WARs had a significantly blunted pre-synaptic response. Rats that did not show limbic seizures showed compensatory upregulation of amygdala 5-HT receptors, a mechanism that failed in rats that developed chronic seizures. Furthermore, WARs showed elevated hypothalamic galanin but reduced limbic receptor expression. The opioid system was also imbalanced, with an increase in the pro-convulsant mu-opioid receptor. Critically, Pdyn expression was strongly and negatively correlated with limbic seizure severity. Collectively, these findings suggest that the progression to limbic epilepsy, already demonstrated in behavioral and EEG protocols in this model, is driven by a widespread failure of plasticity across interconnected neuromodulatory networks, rather than a single molecular defect, highlighting novel targets for therapeutic intervention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.