Evidence map›Paper›PMID 41797309›Full record

ArticleEpigenetics2026

Alterations in epigenetic marks and expression of genes related to stress regulation: an exploratory study among newborns after fetal repair of spina bifida aperta.

M A Landolt, N L Strebel, U Moehrlen, N Ochsenbein, N Strübing, T Burkhardt, C D'Addario, M Pucci, A Bodenmann, E Grünblatt

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Article in Epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M A LandoltDepartment of Psychosomatics and Psychiatry, and Children's Research Center, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-0760-5558
N L StrebelDepartment of Psychosomatics and Psychiatry, and Children's Research Center, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0009-0007-5207-2638
U MoehrlenDepartment of Fetal Surgery, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-6418-1136
N OchsenbeinDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-7691-965X
N StrübingDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-0676-0329
T BurkhardtDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0001-7043-9973
C D'AddarioDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.ORCID 0000-0002-1275-098X
M PucciDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.ORCID 0000-0003-4657-6075
A BodenmannDepartment of Psychosomatics and Psychiatry, and Children's Research Center, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.
E GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8505-7265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fetal repair of spina bifida aperta (fSBA) is an established intervention that improves neurological and neurodevelopmental outcomes. The present exploratory study examines whether molecular signatures related to stress regulation are detectable in newborns following this procedure. Specifically, we investigated DNA methylation and gene expression of two stress-regulatory genes,

Indexed as

DNA MethylationEpigenesis, GeneticReceptors, GlucocorticoidStress, PhysiologicalTacrolimus Binding ProteinsAdultCpG IslandsFemaleFetal TherapiesHumansInfant, NewbornMalePregnancyTacrolimus Binding Protein 5NR3C1 protein, humanReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding ProteinsepigeneticsFKBP5gene methylationNR3C1prenatal stressSpina bifida aperta

Identifiers

PMID41797309
PMCPMC12973468

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.