Evidence map›Paper›PMID 41797709›Full record

ArticleCirculation2026

PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification.

Xi Zhang, Yanglin Hao, Dong Han, Xin Jin, Xiaoke Shang, Li Zhang, Zheng Gan, Weicong Ye, Song Wang, Xiaohan Li and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xi Zhang *Department of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Yanglin Hao *Department of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Dong Han *National Clinical Research Center for Geriatric Diseases, 2nd Medical Center, Chinese PLA General Hospital, Beijing, China (D.H.).
Xin Jin *Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (X.J.).
Xiaoke ShangDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Li ZhangDepartment of Ultrasound Medicine (L.Z.), Wuhan, China.
Zheng GanDepartment of Pain (Z.G.), Wuhan, China.
Weicong YeDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.ORCID 0000-0002-2044-6734
Song WangDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Xiaohan LiDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Ran LiDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Kexiao ZhengDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.ORCID 0009-0005-5107-8857
Yinghuan LiuDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Zifeng ZouDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Zetong TaoDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Yilong LiDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Yongjun WangDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.
Jiahong XiaDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.ORCID 0000-0003-2144-7525
Jie WuDepartment of Cardiovascular Surgery (X.Z., Y.H., X.S., W.Y., S.W., X.L., R.L., K.Z., Y. Liu, Z.Z., Z.T., Y. Li, Y.W., J.X., J.W.), Wuhan, China.ORCID 0000-0002-8880-2520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification remain unclear. Here, we aimed to investigate the role of PRMT3 (protein arginine methyltransferase 3) in valvular calcification and calcific aortic valve disease progression.

methodsBoth aortic valve leaflets and valvular interstitial cells from patients were used to evaluate the expression pattern and investigate the underlying mechanism of PRMT3 in calcific aortic valve disease pathogenesis. High-cholesterol diet-fed Apoe (apolipoprotein E)-deficient (

resultsWe found that PRMT3 expression was significantly upregulated during aortic valve calcification. RUNX2 (runt-related transcription factor 2) recruited P300 to promote PRMT3 expression through histone H3 lysine 27 acetylation. Moreover,

conclusionsWe identify a previously unrecognized posttranslational mechanism regulating PCSK9 stability in valve interstitial cells during calcific aortic valve disease and establish a link between PRMT3-mediated arginine methylation and valve-specific lipid-osteogenic coupling.

Indexed as

Aortic ValveAortic Valve StenosisArginineCalcinosisProprotein Convertase 9Protein-Arginine N-MethyltransferasesAnimalsCore Binding Factor Alpha 1 SubunitHumansMaleMethylationMiceMice, Inbred C57BLMice, Knockout, ApoEArginineCore Binding Factor Alpha 1 SubunitPcsk9 protein, mouseProprotein Convertase 9Protein-Arginine N-Methyltransferasesaortic valveaortic valve diseaseaortic valve stenosislipid metabolismprotein processing

Identifiers

PMID41797709
PMCPMC13200877

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.