Evidence map›Paper›PMID 41797849›Full record

ReviewInfectious medicine2026

The impact of gut microbiota on leukemia and prospects for novel therapies.

Saba Jalalifar, Bahar Bajelan, Reihane Mohammadi, Roya Ghafoury, Zahra Kalhori, Kamran Pooshang-Bagheri, Reza Nekouian, Mohammad Faranoush

Abstract readReview
In one paragraph

Review in Infectious medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Role of Gut Microbiota in Acute Myeloid Leukemia.Journal of clinical medicine · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saba JalalifarPediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran 1593716615, Iran.
Bahar BajelanSchool of Medicine, Alborz University of Medical Sciences, Karaj 3149779453, Iran.
Reihane MohammadiMehresoheila Cancer Charity, Alborz 3139954344, Iran.
Roya GhafouryEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran 1593716615, Iran.
Zahra KalhoriDepartment of Medical Library and Information Science, School of Health Management and Information Science, Iran University of Medical Science, Tehran 1449614535, Iran.
Kamran Pooshang-BagheriVenom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, 1316943551, Iran.
Reza NekouianPediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran 1593716615, Iran.
Mohammad FaranoushPediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran 1593716615, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Human Microbiome Project has underscored the pivotal role of the gut microbiome in human health, revealing its potential influence on leukemia development, progression, and treatment response. This review summarizes evidence on microbiome-targeted therapies such as probiotics, fecal microbiota transplantation, antimicrobial peptides, and nanoparticles. These approaches may improve leukemia treatment outcomes through immune and metabolic modulation and reduced toxicity. Although emerging data suggest beneficial effects, most findings remain correlative and limited by small, heterogeneous studies. Further mechanistic and clinical research is required to clarify causal pathways, standardize interventions, and evaluate long-term safety. Personalized microbiome-based strategies that integrate molecular and immunologic profiling may ultimately refine leukemia management and improve survival.

Indexed as

Fecal microbiota transplantationGut microbiotaLeukemiaMicrobiomeMicrobiome-targeted treatmentProbiotic

Identifiers

PMID41797849
PMCPMC12966719

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.