ArticleCureus2026
Pediatric Hepatobiliary Lithiasis in Homozygous Sickle Cell Disease: Laboratory Insights Into Cholestasis and Hemolysis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic hemolysis in sickle cell disease (SCD) predisposes patients to hepatobiliary complications, including pigment gallstones. We report a 13-year-old girl with hemoglobin SS SCD who presented with right upper quadrant pain, progressive jaundice, and fever. Laboratory evaluation revealed severe anemia with reticulocytosis, mixed hyperbilirubinemia, elevated lactate dehydrogenase, normal cholestatic enzymes, and marked C-reactive protein elevation. Imaging confirmed microlithiasis without significant bile duct obstruction. Supportive care included transfusion, hydration, antibiotics, and pain control. Elective cholecystectomy was planned after stabilization. This case underscores the diagnostic value of combined hemolysis and cholestasis markers for early recognition of hepatobiliary complications in pediatric patients with SCD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.