SynthesisFrontiers in cellular and infection microbiology2026
Laryngeal squamous cell carcinoma: a functional "two-hit" model of papillomavirus-Epstein-Barr virus synergistic carcinogenesis.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Radiomics: Current Applications and Future Directions.MedComm · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking, alcohol consumption, and high-risk human papillomavirus (HPV) infection are recognized risk factors for laryngeal squamous cell carcinoma (LSCC); however, approximately 20%-30% of patients lack typical exposure histories. Furthermore, HPV-positive patients exhibit significant prognostic heterogeneity, suggesting the complexity of multifactorial synergistic carcinogenesis. Recent studies have indicated that the unique anatomy and microenvironment of the larynx may mediate synergistic interactions between pathogens such as Epstein-Barr virus (EBV) and HPV. This functional "two-hit" model drives metabolic reprogramming, disrupts immune responses, and promotes immune evasion, thereby potentially fueling the malignant progression of LSCC. However, coexistence patterns and dynamic interaction mechanisms remain unclear. This systematic review of field advances aims to elucidate potential synergistic mechanisms between HPV and EBV, providing theoretical foundations for pathogen-based multitarget diagnostics and clinical treatment strategies to advance the precision prevention and treatment of LSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.