SynthesisFrontiers in cellular and infection microbiology2026
Vaginal and endometrial microbiota dysbiosis in patients with chronic endometritis: a systematic review and meta-analysis.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Background: Chronic endometritis (CE), a persistent inflammatory condition of the endometrial lining, is clinically linked with adverse reproductive outcomes. It is currently hypothesized to be associated with infection, and is often treated with broad-spectrum antibiotics. However, the specific microbial alterations remain poorly defined due to heterogeneous findings. Methods: PubMed, Web of Science, Medline, Embase, Cochrane Library, and Scopus were searched for studies published up to July 2025. Studies were included if they compared CE patients to non-CE controls and analyzed vaginal or endometrial microbiota. Standardized mean difference (SMD) for alpha-diversity, odds ratio (OR) for microbial detection rates, with 95% confidence intervals (CIs) were calculated. Qualitative syntheses of beta-diversity and microbial abundance profiles were also performed. Result: Twenty-two studies (n = 1274 CE patients, n = 1109 controls) were included. Alpha-diversity indices showed no significant differences for both vaginal and endometrial microbiota. However, a subgroup analysis revealed a significant upregulation in endometrial Chao1 indices in 16S V4 sequencing studies (SMD = 0.38, 95% CI: 0.06 to 0.70, Conclusion: CE is associated with dysbiosis of the vaginal and endometrial microbiota, characterized by a shift from beneficial commensals to pathogenic microbes. This dysbiosis may contribute to an altered the intrauterine immune microenvironment. Systematic review registration: PROSPERO https://www.crd.york.ac.uk/PROSPERO/view/CRD420251115587, identifier CRD420251115587.
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