Evidence mapPaperPMID 41798753Full record

ReviewFrontiers in cellular and infection microbiology2026

Overcoming multidrug resistance: antimicrobial peptides as a next-generation therapeutic strategy.

Shiqi Zhou, Zixuan Sun, Luojia Liu, Yuanyin Xi, Linxi Zhou, Zhibing Yang, Junli Zhou

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiqi Zhou *Department of Burn and Plastic Surgery, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, China.
Zixuan Sun *Department of Orthodontics, College & Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Luojia LiuDepartment of Plastic Aesthetic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University, Chongqing, China.
Yuanyin XiDepartment of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Linxi ZhouDepartment of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Zhibing YangDepartment of Plastic, Reconstructive and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Junli ZhouDepartment of Burn and Plastic Surgery, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amidst the escalating global threat of antibiotic resistance, there is an urgent need for novel antibacterial agents with distinct mechanisms of action to address the impending post-antibiotic era. Antimicrobial peptides (AMPs), membrane-active peptides characterized by rapid bactericidal effects, broad-spectrum activity, and low resistance development potential, are considered promising candidates for overcoming the current multidrug resistance (MDR) crisis. However, the clinical application of AMPs is significantly limited by inherent drawbacks, including susceptibility to proteolytic degradation, poor oral bioavailability, potential mammalian cytotoxicity, low

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacteriaDrug Resistance, Multiple, BacterialAnimalsBacterial InfectionsCell MembraneDrug Delivery SystemsHumansAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptidesantibacterial peptidesantibiotic drug resistanceclinical transformationmechanisms of actionmembrane bioactive peptidesredesign and modify

Identifiers

PMID41798753
PMCPMC12960565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.