Evidence map›Paper›PMID 41798755›Full record

ArticleFrontiers in cellular and infection microbiology2026

Alveolar echinococcosis drives functional reprogramming of hepatic CD8

Jing Tang, Xiaoli Qin, Siyu Hou, Yan Huo, Peijiao Wu, Bingshuo Qian, Yazhou Zhu, Zihua Li, Yinqi Zhao, Yangyang Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jing TangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Xiaoli QinSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Siyu HouSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Yan HuoSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Peijiao WuSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Bingshuo QianDepartment of Pediatrics, General Hospital of Ningxia Medical University, Yinchuan, China.
Yazhou ZhuSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Zihua LiSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Yinqi ZhaoSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Yangyang ZhangDepartment of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan, China.
Tao LiNingxia Key Laboratory for Prevention of Common Infectious Diseases, Yinchuan, China.
Wei ZhaoSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alveolar echinococcosis (AE), caused by the larval stage of Methods: A secondary AE infection model was established by portal vein injection of approximately 1,000 viable protoscoleces in C57BL/6 mice. Liver tissues collected at 3 days (3 dpi) and 3 months (3 mpi) post-infection were analyzed using single-cell RNA sequencing (scRNA-seq), flow cytometry, and multiplex immunofluorescence to characterize T-cell subset composition, transcriptional programs, and potential interactions with dendritic cells (DCs). Results: scRNA-seq of 78,290 high-quality cells identified 13 immune and non-immune populations and revealed strong temporal shifts in hepatic immunity. Early infection featured macrophage-driven inflammation with reduced T-cell proportions, whereas late infection showed marked expansion of both T cells and DCs. CD8 Conclusions: AE infection drives a transition from acute inflammation to chronic immune regulation through extensive lineage diversification and functional reprogramming of CD8

Indexed as

CD8-Positive T-LymphocytesEchinococcosisEchinococcus multilocularisLiverAnimalsDendritic CellsDisease Models, AnimalMiceMice, Inbred C57BLSingle-Cell Gene Expression AnalysisT-Cell ExhaustionT-Lymphocyte Subsetsalveolar echinococcosis (AE)CD8+ T-cell functional reprogrammingcytotoxic/effector-memory/exhausted T cellsdendritic cell–T cell interactionhepatic immune microenvironmentsingle-cell RNA sequencing (scRNA-seq)

Identifiers

PMID41798755
PMCPMC12960575

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.