SynthesisFrontiers in nutrition2026
The role of nutritional supplementation in preventing postoperative complications: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Hospital-acquired infections represent an increasingly urgent issue, particularly in intensive care and surgical settings, also in light of growing concerns about antibiotic resistance. Concurrently, nutrition-due to its immunomodulatory effects-is gaining attention as a key factor across multiple medical disciplines. The aim of this study was to assess perioperative nutritional interventions-immunonutrition, probiotics, synbiotics, and protein integration-in reducing surgical site infections (SSIs), healthcare-associated infections (HAIs) and hospital length of stay (LOS) in surgical patients. Methods: A comprehensive search on principal databases was performed on December 2024. As effect measures, was calculated the Odds Ratios (OR). The assessment of potential bias and the evaluation of study quality was conducted. Thirty-nine publications were selected for inclusion in the meta-analysis. Results: Immunonutrition was associated with a reduction in infectious complications (OR = 0.36) and showed a probable reduction in SSIs (OR = 0.35). Some benefits may also be obtained with the administration of probiotics (OR = 0.61). Bloodstream infections (BSIs) appeared to be substantially reduced with probiotics (OR = 0.42), although the certainty of evidence was low. Analytical studies showed weaker effects than RCTs of immunonutrition on SSI reduction compared with randomized control trials (RCTs), underscoring the importance of RCT evidence for clinical recommendations. Discussion: Based on RCT evidence, immunonutrition demonstrates robust efficacy in preventing SSIs with moderate certainty evidence, and appears ready for clinical implementation in high-risk surgical setting. Probiotics showed moderate effects on selected infectious outcomes, supported by low-certainty evidence, and may be considered as complementary interventions. Protein supplementation demonstrated statistical significance; however, the very low certainty of evidence precludes firm recommendations. Clinical implementation should prioritize interventions supported by RCT evidence within multimodal prevention strategies. Future research should address heterogeneity in nutritional formulations, standardize outcome definitions, and evaluate real-world effectiveness. Systematic review registration: https://www.crd.york.ac.uk/prospero/.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.