Evidence map›Paper›PMID 41799019›Full record

ArticleNeurology open access2026

White Matter Hyperintensities in Behavioral Variant Frontotemporal Dementia and Semantic Variant Primary Progressive Aphasia.

Rafi Hadad, Yann Cobigo, Andjelika Milicic, Elena Tsoy, Maria Luisa Mandelli, Amy A Wolf, Leslie S Gaynor, Katherine L Possin, Isabel Allen, Joel Kramer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rafi HadadStroke and Cognition Institute, Department of Neurology, Rambam Health Care Campus, Haifa, Israel.
Yann CobigoMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA.
Andjelika MilicicGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Elena TsoyGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Maria Luisa MandelliGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Amy A WolfMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA.
Leslie S GaynorMemory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA.
Katherine L PossinGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Isabel AllenGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Joel KramerGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Howard J RosenGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Maria Luisa Gorno-TempiniGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Bruce L MillerGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Victor ValcourGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG048234NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Background and Objectives: White matter hyperintensities (WMH) in patients with cerebrovascular risk factors (CVRF), are often linked to cerebral vascular changes, but can be caused by genetic variants selectively targeting white matter. In addition, WMH can be present in neurodegenerative disorders such as frontotemporal lobar degeneration (FTLD) and are linked to some FTLD genetic variants. This study aims to investigate WMH burden in patients with behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA) versus controls and to evaluates the influence of CVRF. Methods: This cross-sectional retrospective analysis examined individuals meeting research diagnostic criteria for bvFTD and svPPA with high-quality structural MRI at the UCSF Memory and Aging Center between September 2008 and December 2021. WMH burden and spatial distribution were assessed by disease group compared to age- and sex-matched controls and associations with CVRF evaluated. Results: We included 109 individuals with bvFTD [mean age (SD) 62.9 (8.6), 40% female], 47 with svPPA [mean (SD) age 65.4 (7.5), 51% female], and matched controls. After adjusting for age, Discussion: bvFTD and svPPA are associated with elevated WMH burden independent of CVRF. In bvFTD, WMH are primarily distributed within the frontal lobes, while svPPA shows widespread distribution across lobes. Study limitations include its retrospective, single-center design and limited power for genetic subgroup analyses.

Indexed as

[ 25 ] All Cognitive Disorders/Dementia[ 29 ] Frontotemporal dementia[ 35 ] Dementia aphasia

Identifiers

PMID41799019
PMCPMC12962591

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.