ArticleACS omega2026
BBB Permeability and Cytotoxic Profiles of Tea Phytoconstituents via Nanoliposomes.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tea-derived phytoconstituents hold promise for neurotherapeutics, but their clinical application is severely limited by poor blood-brain barrier (BBB) penetration and potential cytotoxicity. Unmodified phytochemicals such as theaflavin and quercetin exhibit negligible BBB delivery (<2%) and require high, toxic doses to achieve neuroprotective effects. We encapsulated six tea bioactives, gallic acid, caffeine, chlorogenic acid, quercetin, EGCG, and theaflavin, into nanoliposomes (phosphatidylcholine/cholesterol = 3:1), creating stable nanovesicles (42.6-85.3 nm, zeta potential 28.6 to -57.2 mV) designed to enhance brain delivery. Encapsulation efficiencies ranged from 51.4% (theaflavin) to 87.8% (caffeine). Cytotoxicity assays (MTT, 100-500 μM) showed EGCG and caffeine were safe, while chlorogenic acid, theaflavin, and quercetin exhibited dose-dependent toxicity, with liposome encapsulation shifting IC
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Registered trials
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