Evidence map›Paper›PMID 41799190›Full record

ArticleTheranostics2026

Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.

Pengxiang Zhao, Han Li, Zisong Cai, Xujuan Zhang, Xiaohu Wen, Ziyi Liu, Shihao Jiang, Xue Jiang, Jiateng Wang, Zheng Dang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. LongitudinalIn vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pengxiang ZhaoCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Han LiCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Zisong CaiCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Xujuan ZhangCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Xiaohu WenCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Ziyi LiuCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Shihao JiangCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Xue JiangCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Jiateng WangCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Zheng DangCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Mengyu LiuCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Fei XieCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.
Xuemei MaCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: Hydrogen gas (H Methods: This study employed real-time calcium imaging and CRISPR-Cas9 gene editing, with live-cell imaging to monitor real-time calcium signal intensity in living cells. Two-photon Results: H Conclusions: This study identifies H

Indexed as

CalciumCalcium SignalingHydrogenTRPC Cation ChannelsAnimalsCell MovementHumansMiceMice, Inbred C57BLMolecular Docking SimulationMolecular Dynamics SimulationCalciumHydrogenTRPC4 ion channelTRPC Cation Channelscalcium ioncalcium transientgasotransmittermolecular hydrogenTRPC4TRPC4AP

Identifiers

PMID41799190
PMCPMC12964245

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.