Evidence map›Paper›PMID 41799200›Full record

ArticleTheranostics2026

CEBPB-high dormant tumor cells drive immune evasion via S100A8 orchestrated tumor-associated macrophages reprogramming.

Jin Bai, Huilan Su, Shunxi Wang, Yang Dong, Yong Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jin BaiDepartment of Oncology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong District, Shanghai, 200120, China.
Huilan SuResearch Center for Translational Medicine, Cancer Stem Cell Institute, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong District, Shanghai, 200120, China.
Shunxi WangInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and The Key Laboratory of Tumor Immunopathology, The Ministry of Education of China, Chongqing, 400038, China.
Yang DongResearch Center for Translational Medicine, Cancer Stem Cell Institute, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong District, Shanghai, 200120, China.
Yong GaoDepartment of Oncology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong District, Shanghai, 200120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: Triple negative breast cancer (TNBC) poorly responds to immune checkpoint blockade (ICB) therapy. Dormant tumor cells are recognized as immunotherapy-resistant reservoirs that may lead to tumor relapse, although the underlying mechanisms remain to be fully elucidated. Methods: Public scRNA-seq data was employed to identify dormant tumor cells in TNBC patients receiving ICB therapy. A TetOn-H2BeGFP system was used to label and track dormant tumor cells both Results: We demonstrated that dormant tumor cells were resistant to ICB and resided within an immunosuppressive niche, characterized by increased M2 macrophages and reduced CD8 Conclusions: Our study demonstrate a mechanistic link between tumor dormancy and immune evasion, highlighting the CEBPB-S100A8 axis as a promising therapeutic target to potentiate ICB efficacy in TNBC.

Indexed as

Calgranulin ACCAAT-Enhancer-Binding Protein-betaMacrophagesTriple Negative Breast NeoplasmsTumor-Associated MacrophagesTumor EscapeAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansImmune Checkpoint InhibitorsMiceTumor MicroenvironmentCalgranulin ACCAAT-Enhancer-Binding Protein-betaCEBPB protein, humanImmune Checkpoint InhibitorsS100A8 protein, humanCEBPBDormant tumor cellsimmune checkpoint blockademacrophagesS100A8

Identifiers

PMID41799200
PMCPMC12964385

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.