Evidence map›Paper›PMID 41799257›Full record

ReviewCurrent research in food science2026

Factors influencing gut microbial colonization: A host-microbe-environment interaction perspective.

Yan Zhao, Zhangheng Ren, Qinyu Xu, Ting Zhu, Huanhuan Hu, Yanghong Fu, Jinchi Jiang, Qixiao Zhai

Abstract readReview
In one paragraph

Review in Current research in food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Programming the tumor microenvironment through microbiome-driven mechanisms.Frontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan ZhaoJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, 222005, China.
Zhangheng RenJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, 222005, China.
Qinyu XuJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, 222005, China.
Ting ZhuClinical Nutrition Department, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210008, China.
Huanhuan HuJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, 222005, China.
Yanghong FuJiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang, 222005, China.
Jinchi JiangCollege of Food Science and Light Industry, Nanjing Tech University, Nanjing, 211816, China.
Qixiao ZhaiState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbial colonization is a dynamic balance shaped by host genetics and immunity, microbial ecology, and environmental exposures. This review synthesizes evidence on host barriers and immunity-mucus architecture, antimicrobial peptides, pattern recognition receptors, and secretory IgA-and on genetic loci such as LCT and ABO/FUT2 that modulate nutrient landscapes and strain selection. Microbial adaptability is summarized, including polysaccharide utilization loci and human milk oligosaccharide metabolism, bile salt hydrolase-mediated tolerance, extracellular polysaccharide-driven immune modulation, oxygen-gradient-linked metabolic partitioning, and adhesion mechanisms that secure niche occupancy. Environmental perturbations are evaluated, spanning dietary patterns, protein sources, polyphenols, food additives, pharmaceuticals, and lifestyle factors such as physical activity, circadian alignment, and smoking, which reshape resource competition, barrier integrity, and community resilience. Interaction frameworks that govern stability and dysbiosis are delineated, including competitive inhibition, cross-feeding, quorum sensing, cross-kingdom crosstalk among bacteria, fungi, and phages, and horizontal gene transfer that accelerates adaptation and resistance. Niche elasticity is proposed as a systems metric to quantify stability and recovery after perturbation. Translational strategies combine engineered probiotics, anti-adhesion approaches, and rationally designed phages and lysins with in situ multi-omics to enable mechanism-guided, personalized interventions for food science and microbial engineering.

Indexed as

ColonizationGut microbiotaHost-microbe interactionMicrobial ecological adaptation

Identifiers

PMID41799257
PMCPMC12966602

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.