Evidence map›Paper›PMID 41799438›Full record

ArticleFrontiers in cell and developmental biology2026

Restoring

Anastasiya V Kosykh, Elena B Zhigmitova, Nadezhda A Evtushenko, Tatyana H Gurskaia, Aleksandra A Martynova, Yuliya Yu Silaeva, Anastasiia S Ivanova, Natalia Y Martynova, Maria B Tereshina, Stanislav G Rudyak and 5 more

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In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anastasiya V KosykhPirogov Russian National Research Medical University, Moscow, Russia.
Elena B ZhigmitovaPirogov Russian National Research Medical University, Moscow, Russia.
Nadezhda A EvtushenkoPirogov Russian National Research Medical University, Moscow, Russia.
Tatyana H GurskaiaPirogov Russian National Research Medical University, Moscow, Russia.
Aleksandra A MartynovaPirogov Russian National Research Medical University, Moscow, Russia.
Yuliya Yu SilaevaInstitute of Gene Biology, Moscow, Russia.
Anastasiia S IvanovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Natalia Y MartynovaPirogov Russian National Research Medical University, Moscow, Russia.
Maria B TereshinaPirogov Russian National Research Medical University, Moscow, Russia.
Stanislav G RudyakPirogov Russian National Research Medical University, Moscow, Russia.
Andrey A PanteleyevPirogov Russian National Research Medical University, Moscow, Russia.
Helen P MakarenkovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Nadya G GurskayaPirogov Russian National Research Medical University, Moscow, Russia.
Sergey A LukyanovPirogov Russian National Research Medical University, Moscow, Russia.
Andrey G ZaraiskyPirogov Russian National Research Medical University, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue and organ regeneration is a remarkable ability observed in many animal species, which has been significantly reduced or lost in several vertebrate lineages, partly due to the evolutionary loss of regeneration-associated genes. For example, many genes involved in limb and skin regeneration in anamniotes (fish and amphibians) have been lost in amniotes (reptiles, birds, and mammals) following their transition to terrestrial life. This raises the intriguing question of whether reintroducing such lost genes could partially restore regenerative abilities. Here, we investigated whether the ag1 gene, which plays a key role in regeneration in fish and amphibians and was lost in amniotes, could enhance skin wound healing in mice. We generated transgenic mice with inducible expression of the

Indexed as

AG1genes lost in evolutionskinskin wound healingtet on expressiontransgenic miceXenopus

Identifiers

PMID41799438
PMCPMC12960510

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.