Evidence map›Paper›PMID 41799625›Full record

ArticleFood chemistry: X2026

An innovative strategy coupling cluster fraction with ultrafiltration UPLC-QTOF-MS/MS for screening α-glucosidase inhibitors from barley seedlings.

Changdong Lin, Juyuan Luo, Shuo Wang, Cheng Shen, Shucan Zhang, Yongling Liu, Zhibo Song, Yumei Ma, Tao Chen, Yulin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changdong LinSchool of Ecological and Environmental Engineering, Qinghai University, Xining 810016, China.
Juyuan LuoNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Shuo WangNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Cheng ShenNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Shucan ZhangSchool of Ecological and Environmental Engineering, Qinghai University, Xining 810016, China.
Yongling LiuNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Zhibo SongNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Yumei MaNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Tao ChenNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.
Yulin LiNorthwest Institute of Plateau Biology Chinese Academy of Sciences, Xining 810008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Affinity ultrafiltration is widely used for rapid, targeted screening of bioactive natural compounds, but high-abundance components in complex matrices often mask low-abundance yet potent inhibitors, reducing sensitivity. Here, barley seedling extracts were preprocessed via HPLC peak-area clustering before affinity ultrafiltration to identify α-glucosidase inhibitors. This "clustering-prior-to-ultrafiltration" strategy enabled the discovery of four additional low-abundance inhibitors overlooked by direct ultrafiltration. These compounds exhibited stronger inhibitory activity (IC

Indexed as

Cluster fractionMolecular dynamics simulationMultispectralUltrafiltrationUPLC-QTOF-MS/MSα-Glucosidase

Identifiers

PMID41799625
PMCPMC12966689

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.