Evidence map›Paper›PMID 41800069›Full record

ArticleInternational journal of pharmaceutics: X2026

Hypoxia-relieving and glycolysis-disrupting polydopamine nanomedicine for synergistic chemo-photothermal therapy of hepatocellular carcinoma.

Xiang Wang, Yihan Ma, Le Wang, Hengrui Li, Miao Qin, Ruonan Sun, Jing Hu

Abstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiang WangWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Yihan MaWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Le WangSchool of Biotechnology and Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.
Hengrui LiWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Miao QinWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Ruonan SunWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Jing HuWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia is a hallmark of solid tumors that compromises therapeutic efficacy in hepatocellular carcinoma (HCC). Here, a multifunctional polydopamine (PDA)-based nanomedicine co-loading shikonin (SK) and catalase (CAT) and functionalized with galactose (Gal) is developed and termed SC@PDA-Gal. SC@PDA-Gal delivers SK to inhibit pyruvate kinase M2 (PKM2) and disrupt glycolytic output, while the co-delivered CAT decomposes endogenous H

Indexed as

Chemo-photothermal therapyGlycolysisHepatocellular carcinomaPyruvate kinase M2Shikonin

Identifiers

PMID41800069
PMCPMC12962110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.