Evidence map›Paper›PMID 41800264›Full record

ArticleInternational journal of biological sciences2026

USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination.

Jia Cheng, Fang Fang, Zhiheng Li, Jianwei Wang, Linbo Cai, Ling Xu, Yanfang Tao, Juanjuan Yu, Gen Li, Zimu Zhang and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jia ChengChildren's Hospital of Soochow University, Suzhou 215003, China.
Fang FangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Zhiheng LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Jianwei WangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Linbo CaiChildren's Hospital of Soochow University, Suzhou 215003, China.
Ling XuDepartment of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China.
Yanfang TaoDepartment of Traditional Chinese Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Juanjuan YuChildren's Hospital of Soochow University, Suzhou 215003, China.
Gen LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Zimu ZhangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Zexi CuiDepartment of Medicinal Chemistry, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Yang YangInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Tiandan LiChildren's Hospital of Soochow University, Suzhou 215003, China.
Di WuInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Xiaolu LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Yifang DingDepartment of Pediatrics, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou 215600, China.
Zong ZhaiDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Mengmeng GuDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Xue LiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Xingxing WuDepartment of Pediatrics, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou 215600, China.
Pengju YangChildren's Hospital of Soochow University, Suzhou 215003, China.
Chunxia ShiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Huike BaiInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Xiaodong WangDepartment of Orthopaedics, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Lanlan HanInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Lei ShiDepartment of Medicinal Chemistry, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Jianqin LiDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
Jian PanInstitute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy driven by genetic and epigenetic alterations, where super-enhancers (SEs) play key oncogenic roles, representing promising therapeutic targets in AML. Through H3K27ac ChIP-seq profiling of 7 AML cell lines and 13 primary samples, we identified USP20 as the deubiquitinase that most frequently associated with super-enhancers. Public database analysis confirmed USP20 overexpression in AML and its correlation with adverse prognosis. Genetic knockdown of USP20 via shRNA significantly induced apoptosis and suppressed proliferation in AML cells

Indexed as

beta CateninLeukemia, Myeloid, AcuteUbiquitin ThiolesteraseAnimalsApoptosisCell Line, TumorCell ProliferationHumansMiceSuper EnhancersUbiquitinationbeta CateninCTNNB1 protein, humanUbiquitin ThiolesteraseAMLAS1517499CTNNB1super-enhancerUSP20

Identifiers

PMID41800264
PMCPMC12965243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.