ArticleFuture science OA2026
Glucosamine induces apoptosis of cholangiocarcinoma cells by suppressing high-mannose type
Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
aimThis study aimed to investigate the effects of glucosamine, a glucose analogue mainly transported via glucose transporter (GLUT) 2, on the progression of cholangiocarcinoma (CCA) cells.
methodsDifferential expressions of GLUTs in CCA and normal bile ducts were analyzed using a public transcriptomic dataset. The effects of glucosamine on CCA cell viability and proliferation were examined using an MTT assay and flow cytometry. Molecular mechanisms were investigated using Western blots and lectin blots.
resultsGLUT2 expression was significantly decreased in CCA compared with the normal bile duct tissues. Glucosamine significantly reduced CCA cell viability in a dose-dependent manner (
conclusionGlucosamine exerted anti-cancer effects on CCA cells, suggesting its potential for further study as a repurposing drug for CCA.
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