Evidence map›Paper›PMID 41801298›Full record

ReviewJournal of natural medicines2026

Chemistry and bioactivities of erinacines from Hericium fungi.

Yhiya Amen, Ahmed Othman, Kuniyoshi Shimizu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yhiya Amen *Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. yhiaamen@mans.edu.eg.ORCID http://orcid.org/0000-0003-2552-4567
Ahmed Othman *Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University, Cairo, 11884, Egypt.ORCID http://orcid.org/0000-0002-2827-7621
Kuniyoshi ShimizuDepartment of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan. shimizu.kuniyoshi.381@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0001-5960-1503

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erinacines are a class of cyathane diterpenoids predominantly biosynthesized in the mycelia of the medicinal mushroom Hericium erinaceus, commonly known as Lion’s Mane or Yamabushitake. Recognized as the main constituents responsible for the neurological effects of Hericium species, erinacines exhibit a range of biological properties, including anti-inflammatory, neurotrophic, neurogenic, antidepressant, and anticancer activities, as well as κ-opioid receptor agonist activity. This review provides a detailed analysis of the pharmacological potential of the twenty-three erinacines reported to date, along with their comprehensive nuclear magnetic resonance (NMR) characterization. This work underscores the promise of erinacines as valuable lead compounds for the development of therapeutic agents.

Indexed as

DiterpenesHericiumAnimalsAnti-Inflammatory AgentsAntineoplastic AgentsHumansMagnetic Resonance SpectroscopyAnti-Inflammatory AgentsAntineoplastic AgentsDiterpenesErinacinesHericium erinaceusMedicinal mushroomsNerve growth factorNeuroprotection

Identifiers

PMID41801298

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.