Evidence map›Paper›PMID 41801548›Full record

ArticleInternational ophthalmology2026

Corneal biomechanics alterations and increased risk for corneal ectasia in Turner syndrome.

Anna Maria Roszkowska, Maura Mancini, Ludovica Gargiulo, Giorgia Pepe, Romana Gargano, Tommaso Aversa, Malgorzata Wasniewska

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna Maria RoszkowskaOphthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, Italy. aroszkowska@unime.it.ORCID http://orcid.org/0000-0002-8083-3437
Maura ManciniOphthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, Italy.
Ludovica GargiuloOphthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, Italy.
Giorgia PepeDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Romana GarganoDepartment of Economics, University of Messina, Messina, Italy.
Tommaso AversaDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Malgorzata WasniewskaDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess corneal tomographic parameters and biomechanics of patients with Turner syndrome.

methodsThirty-four eyes of 17 patients with Turner Syndrome (TS) and 20 eyes of 10 healthy females were evaluated for corneal parameters and biomechanics. The main outcome measures were anterior and posterior keratometry (K-meanAnt and K-meanPost) anterior and posterior elevation (AE, PE), central corneal thickness (CCT), anterior and posterior Q values (QAnt and QPost), corneal volume (CV), Belin-Ambrosio Tomographic Index (BAD), and biomechanical parameters such as Corneal Biomechanical Index (CBI), and Tomography-Biomechanical Index (TBI). The group of patients with TS was compared to a control group for all evaluated parameters.

resultsSignificantly higher values of PE, CCT, CV, BAD, and TBI were observed in Turner Syndrome. The TS group displayed significantly lower K-meanPost, QAnt, and QPost values. BAD, CBI, and TBI values exceeding the cut off were observed in nine eyes (26.47%) in the TS group and three eyes (15%) in the control group. Patients with TS showed altered BAD values (odds ratio of 4.88). The TBI index was altered, with an odds ratio of 7.33, suggestive for significantly higher risk of ectasia. The CBI index was unvaried between groups. The cases with pathological BAD value were observed in individuals with mosaicism, suggesting a potential link between this karyotype and BAD alterations.

conclusionsPatients with TS exhibit altered biomechanical values indicating a significant risk for corneal ectasia. Periodic monitoring of corneal parameters in this population is necessary to detect early signs of ectasia.

Indexed as

CorneaElasticityKeratoconusTurner SyndromeAdolescentAdultBiomechanical PhenomenaChildCorneal TopographyDilatation, PathologicFemaleHumansRisk FactorsYoung AdultCorneal biomechanicsCorneal ectasiaCorneal tomographyTurner syndrome

Identifiers

PMID41801548

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.