Observational studyEndocrine2026
Long-term body composition changes after bariatric surgery and their association with fat- and bone-derived hormones.
Observational study in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions.Frontiers in endocrinology · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBariatric surgery effectively reduces obesity-related comorbidities, however fat mass loss is often accompanied by lean mass reduction. This 36-month prospective study (N=55) examined body composition changes following three bariatric procedures compared with a diet-controlled group (Diet).
methodsRandom intercept mixed-effects models assessed 36-month trajectories of fat and lean mass, comparing surgical groups with Diet, adjusting for age and sex. Associations between body composition changes, measured by dual-energy X-ray absorptiometry and adiponectin (fat-derived) and undercarboxylated osteocalcin (ucOC; bone-derived) hormones were evaluated at 0, 1, 3, 6, 12, 24, and 36 months.
resultsRoux-en-Y gastric bypass produced the greatest fat mass loss (46.6%), followed by sleeve gastrectomy (30.1%) and laparoscopic adjustable gastric banding (20.5%). Corresponding lean mass losses were 14.2%, 11.7%, and 5.2%. In Diet changes in fat mass (−2.1%) and lean mass (+3.6%) were non-significant. Over 36 months, all surgical groups lost significantly more lean mass than Diet, with the greatest losses after RYGB (15.1%) and LAGB (14.8%). Women experienced 30% greater lean mass loss than men (95% CI: -34%, -26%). Each additional year of age was associated with a 0.2% lean mass decline (95% CI: -0.5%, 0%). After controlling for treatment procedure, age and sex, each twofold increase in adiponectin and ucOC was associated with 5.0% (95% CI: -9.4%, -2.4%) and 3.7% (95% CI: -5.0%, -1.3%) reductions in lean mass, respectively.
conclusionsThese findings underscore the lean mass loss risk after bariatric surgery, particularly in women and older adults, and highlight the importance of long-term monitoring of body composition, nutrition and bone health. CLINICAL
trial registrationThe study was registered as ANZCTR: 12613000188730.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.