Independent and combined associations of maternal one-carbon nutrition biomarkers and dietary patterns with epigenetic age acceleration: Evidence from the Boston Birth Cohort.

Nusrat Jabin, Guoying Wang, Xiumei Hong, Serena Rusk, Tina L Cheng, Xiaobin Wang

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Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Nusrat JabinCenter On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0009-0000-1101-3454

Guoying WangCenter On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Xiumei HongCenter On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Serena RuskCenter On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Tina L ChengCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.

Xiaobin WangCenter On the Early Life Origins of Disease, Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA. xwang82@jhu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy functions as a "stress test" with implications for women's long-term health. We hypothesize that maternal biological aging, measured by epigenetic age acceleration (EAA), can be influenced by one-carbon nutritional status (folate, vitamin B₁₂, homocysteine), adherence to the Mediterranean diet, and prenatal multivitamin use. We analyzed data from 742 mothers enrolled in the Boston Birth Cohort (1998-2013). EAA was defined as the difference between the Levine epigenetic clock-DNA methylation-based measure and chronological age at delivery. Mediterranean-diet adherence and prenatal multivitamin use were assessed using a validated food frequency questionnaire administered within 24-72 h postpartum. Blood DNA and plasma samples used to measure folate, B

Indexed as

Boston Birth CohortEpigenetic aging accelerationHomocysteineMediterranean dietMultivitaminOne-carbon micronutrientsPlasma folateVitamin B12

Identifiers

PMID41801618

DOI10.1016/j.cmet.2016.08.009

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