Evidence map›Paper›PMID 41801818›Full record

ArticleJournal of chemical information and modeling2026

Cyclin-E/A/CDK1/2 Kinetic Landscapes Drive Cell Cycle Phase-Specific Progression and Guide Cyclin-E Degradation Strategy.

Wengang Zhang, Devin Bradburn, Yonglan Liu, Hyunbum Jang, Mardo Kõivomägi, Ruth Nussinov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wengang ZhangCancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0001-9653-6966
Devin BradburnLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, United States.
Yonglan LiuCancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.
Hyunbum JangCancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0001-9402-4051
Mardo KõivomägiLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, United States.
Ruth NussinovCancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.ORCID 0000-0002-8115-6415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell cycle relies on sequential activation of cyclin-dependent kinases (CDKs) by phase-specific cyclins. Previously, we proposed that their conformations and activation speed are tuned to the needs of their respective phases. We demonstrated this principle by using molecular dynamics simulations to evaluate the slower activation and catalytic kinetics of Cyclin-D/CDK4 during the long G

Indexed as

CDC2 Protein KinaseCell CycleCyclin ACyclin-Dependent Kinase 2Cyclin EProteolysisKineticsMolecular Dynamics SimulationProtein ConformationCDC2 Protein KinaseCyclin ACyclin-Dependent Kinase 2Cyclin E

Identifiers

PMID41801818
PMCPMC13014447

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.