Evidence map›Paper›PMID 41803004›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2026

Protective Effects of Pentoxifylline on Peripheral Microcirculatory Dysfunction and Renal Cortical Oxygen Deficiency in a Rat Model of LPS-Induced Sepsis.

Bülent Ergin, H Rob Taal, Deniz Erol Kutucu, Wijnie van Dam, Aysegul Kapucu, Sinno S H P Simons, Can Ince, Irwin K M Reiss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bülent ErginDepartment of Intensive Care Adult, Laboratory of Translational Intensive Care, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-2486-3711
H Rob TaalDepartment of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Hospital Rotterdam, Rotterdam, the Netherlands.
Deniz Erol KutucuDepartment of Zoology, Faculty of Science, University of Istanbul, Istanbul, Turkey.
Wijnie van DamDepartment of Intensive Care Adult, Laboratory of Translational Intensive Care, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Aysegul KapucuDepartment of Zoology, Faculty of Science, University of Istanbul, Istanbul, Turkey.
Sinno S H P SimonsDepartment of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Hospital Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0001-5219-5696
Can InceDepartment of Intensive Care Adult, Laboratory of Translational Intensive Care, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Irwin K M ReissDepartment of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Hospital Rotterdam, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSepsis is associated with hypotension, tissue hypoperfusion, and microcirculatory dysfunction leading to multi-organ failure and mortality. Pentoxifylline (PTX), a phosphodiesterase inhibitor, is reported to improve blood flow and viscosity. The aim of this study was to investigate the efficacy of PTX on peripheral and renal microcirculatory alterations in sepsis.

methodsFully instrumented Wistar albino rats were randomized as the control group (only surgery), only lipopolysaccharide (LPS) group without treatment (T1), LPS group with PTX treatment (LPS + PTX), LPS group treated with only fluid resuscitation (Ringer's acetate; RA), LPS + RA, LPS group with combined treatment with PTX and RA (LPS + PTX + RA) for 3 h (T2, T3 and T4). The systemic hemodynamics, renal oxygenation, leg muscle microcirculation, histological damage, and inflammatory and endothelial injury markers were analyzed.

resultsThe renal cortical microvascular oxygen pressure (cμPO

conclusionIn this study, we found that PTX may protect renal oxygenation, peripheral (muscle) microcirculation, renal damage, and tissue inflammatory cell infiltration in a rat model of LPS-induced sepsis.

Indexed as

Kidney CortexLipopolysaccharidesMicrocirculationOxygenPentoxifyllineSepsisAnimalsDisease Models, AnimalMaleRatsRats, WistarLipopolysaccharidesOxygenPentoxifyllinemicrocirculationoxygenationrenal dysfunctionsepsis

Identifiers

PMID41803004
PMCPMC12971620

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.