ArticleCancer medicine2026
CBX3:IL1RN Reflects Distinct Cellular States That Defines the Clinical Outcome of Oral Squamous Cell Carcinoma.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundOral squamous cell carcinoma (OSCC) exhibits heterogeneous therapeutic outcomes owing to various tumor microenvironments (TMEs). Previous studies have classified OSCC according to its molecular characteristics; however, clinical practice is limited by technical complexity.
methodsA total of 33 patients from five single-cell datasets of primary OSCC were integrated for CMS classification. The correlation between CMS classification and prognosis was analyzed with integrated bulk transcriptomics. Top scoring pairs (TSPs) algorithm was used to identify the gene pair that effectively captures the information of CMS classification. The selected gene pair was ultimately validated in independent single-cell data, spatial transcriptomics and immunofluorescence assays.
resultsOSCC patients were stratified into two distinct molecular subtypes (CMS1 and CMS2) harboring diverse prognostic levels, therapeutic vulnerabilities, microenvironmental characteristics, and malignant behaviors. Furthermore, CBX3 and IL1RN were identified as signature genes whose expression ratio (CBX3:IL1RN) effectively captures the critical features of CMS classification. Patients whose CBX3:IL1RN > 1 exhibited characteristics of CMS1 subtype with worse outcomes and more active malignant behaviors, vice versa. Further analyses implicated epithelial-mesenchymal transition (EMT) as a potential mechanism through which this ratio may modulate tumor progression. Finally, our finding was validated with our clinical samples and confirmed the ratio of CBX3:IL1RN was related to T and N stages.
conclusionThis study presents a simplified and clinically applicable OSCC classification system based on CBX3:IL1RN. And provide a practical tool for OSCC subtyping with implications for prognosis prediction and personalized treatment strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.