Evidence map›Paper›PMID 41803144›Full record

ArticleNature communications2026

Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors.

Raúl Sánchez-Lanzas, Amanda Jiménez-Pompa, Elise Smith, Nital Sumaria, Justin Barclay, Foteini Kalampalika, Daniel J Pennington, Mirjana Efremova, Miguel Ganuza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raúl Sánchez-LanzasCentre for Haemato-Oncology - Barts Cancer Institute, Queen Mary University of London, London, UK.
Amanda Jiménez-PompaCentre for Haemato-Oncology - Barts Cancer Institute, Queen Mary University of London, London, UK.
Elise SmithCenter for Cancer Genomics and Computational Biology - Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0431-4942
Nital SumariaCentre for Immunobiology - Blizzard Institute, Queen Mary University of London, London, UK.
Justin BarclayCentre for Haemato-Oncology - Barts Cancer Institute, Queen Mary University of London, London, UK.
Foteini KalampalikaCentre for Haemato-Oncology - Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-5565-3928
Daniel J PenningtonCentre for Immunobiology - Blizzard Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-7889-9923
Mirjana EfremovaCenter for Cancer Genomics and Computational Biology - Barts Cancer Institute, Queen Mary University of London, London, UK. m.efremova@qmul.ac.uk.ORCID http://orcid.org/0000-0002-8107-9974
Miguel GanuzaCentre for Haemato-Oncology - Barts Cancer Institute, Queen Mary University of London, London, UK. m.ganuza@qmul.ac.uk.ORCID http://orcid.org/0000-0002-1070-7961

Funding

American Society of Hematology (ASH) Global Research Award, ASH GRA 2021Cancer Research UK (CRUK) Establishment Award, RCCCEA/100003Cancer Research UK (CRUK) PhD FellowshipRCUK | Medical Research Council (MRC) MRC Career Development Award, MR/V009222/1RCUK | Medical Research Council (MRC) PhD studentship
6 · The paper itself

Abstract

Cellular interactions between thymocytes and other immune and stromal thymic cells play a key role in T cell maturation and homeostasis. Previous efforts delineating the cellular interactomes that support T cell development have mostly relied on imaging techniques, genetic deletion of essential molecular factors and bone marrow chimeras. Here, using synthetic NOTCH receptors we took a direct and unbiased genetic approach to fluorescently label cells in physical contact with CD4

Indexed as

Cell CommunicationReceptors, NotchThymocytesThymus GlandAnimalsB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationDendritic CellsEpithelial CellsFibroblastsMiceMice, Inbred C57BLSignal TransductionReceptors, Notch

Identifiers

PMID41803144
PMCPMC13102935

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.