Evidence map›Paper›PMID 41803291›Full record

ArticleFunctional & integrative genomics2026

MYC-SEPT11 Axis Promotes osteoblast differentiation and bone formation via PI3K/AKT and RhoA/ROCK signaling pathways.

Yiwen Zhao, Zhenghuan Zhu, Haining Chen, Yu Song, Feng Wang, Zhihui Huang, Wenming Ma, Wenge Ding, Jinbo Liu

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In one paragraph

Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiwen Zhao *Department of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China.
Zhenghuan Zhu *Department of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China.
Haining ChenDepartment of Orthopedics, Affiliated Hospital of Jiangsu University, Jiangsu University, 438 Jiefang Road, Zhenjiang, 212000, China.
Yu SongDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China.
Feng WangDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China.
Zhihui HuangDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China.
Wenming MaDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China.
Wenge DingDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China. dwg1475@suda.edu.cn.
Jinbo LiuDepartment of Orthopedics, Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, 185 Juqian Road, Changzhou, 213000, Jiangsu, China. czljbljb@126.com.

Funding

the Clinical Research Program of the Third Affiliated Hospital of Soochow University Changzhou First People's Hospital Office [2024] 126the Young Talent Science and Technology Project of Changzhou Health Commission QN202108
6 · The paper itself

Abstract

Osteoporosis (OP), an aging-related skeletal disorder characterized by compromised bone density and deteriorated microarchitecture, presents significant challenges in understanding its molecular underpinnings. This study aims to identify novel transcriptional regulators of osteoblast differentiation and elucidate their mechanistic roles in OP pathogenesis. Through integrated analysis of single-cell and bulk RNA-seq datasets from OP patients, combined with machine-learning algorithms, SEPT11 was identified as a key downregulated gene. Functional validation was performed using human bone marrow-derived mesenchymal stem cells (BM-MSCs) induced for osteogenic differentiation. SEPT11 was overexpressed through lentiviral transduction, with osteogenic capacity assessed by ALP staining, Alizarin Red S staining, and quantification of osteogenic markers (RUNX2, OCN, ALP, PINP) and bone resorption marker TRACP-5b. Mechanistic investigations employed chromatin immunoprecipitation (ChIP)-qPCR, dual-luciferase reporter assays, and pathway inhibition studies. An ovariectomized (OVX) mouse model received intra-articular AAV9-SEPT11 for in vivo validation, with bone microarchitecture analyzed by micro-CT and bone formation markers measured. SEPT11 was significantly downregulated in OP and positively correlated with osteogenic differentiation. In BM-MSCs, SEPT11 overexpression enhanced expression of RUNX2, OCN, ALP, and PINP, decreased TRACP-5b, increased mineralization capacity, and concurrently activated both PI3K/AKT and RhoA/ROCK signaling pathways. MYC was established as a direct transcriptional activator binding to the SEPT11 promoter. MYC knockdown abolished SEPT11-mediated osteogenic promotion and pathway activation. In OVX mice, AAV9-SEPT11 administration improved bone mass, restored trabecular micro-architecture, and elevated bone formation markers. This study identifies a previously uncharacterized MYC/SEPT11 regulatory axis crucial for osteoblast differentiation. SEPT11, transcriptionally activated by MYC, promotes osteogenesis through simultaneous activation of PI3K/AKT and RhoA/ROCK pathways. These findings provide novel insights into OP pathogenesis and suggest potential therapeutic targets for postmenopausal OP.

Indexed as

Cell DifferentiationOsteoblastsOsteogenesisOsteoporosisProto-Oncogene Proteins c-mycSeptinsAnimalsFemaleHumansMesenchymal Stem CellsMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrhoA GTP-Binding Proteinrho-Associated KinasesSignal TransductionMYC protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycrhoA GTP-Binding Proteinrho-Associated KinasesSeptinsMYCosteoblast differentiationosteoporosisSEPT11

Identifiers

PMID41803291

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.