Evidence map›Paper›PMID 41803788›Full record

ArticleBMC women's health2026

Association between menstrual cycle length and ovarian reserve markers and stimulation response: a retrospective cohort study.

Gökçe Aykanat, Begüm Ertan, Fatma Tulucu Kalkan, Ufuk Atlıhan, Ferruh Acet, Ege Nazan Tavmergen Goker, Erol Tavmergen

Abstract read
In one paragraph

Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gökçe AykanatKınık State Hospital, Izmir, Türkiye.
Begüm ErtanAkhisar State Hospital, Manisa, Türkiye.
Fatma Tulucu KalkanGaziantep City Hospital, Gaziantep, Türkiye.
Ufuk AtlıhanIzmir Democracy University, Izmir, Türkiye. cfl.ufuk@gmail.com.
Ferruh AcetTavmergen IVF Clinic, Izmir, Türkiye.
Ege Nazan Tavmergen GokerEge University Faculty of Medicine, Izmir, Türkiye.
Erol TavmergenEge University Faculty of Medicine, Izmir, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the relationship between menstrual cycle length (MCL) categories and ovarian reserve biomarkers and controlled ovarian stimulation (COS) response levels. MATERIALS AND

methodsMedical records of women undergoing infertility evaluations between January 2022 and April 2025 were reviewed. A total of 550 women undergoing fresh IVF/ICSI cycles were screened for eligibility, and 440 normo-ovulatory women who met all inclusion criteria were included. Patients were grouped according to MCL (21–28 and 29–35 days). Demographic characteristics (age, body mass index), baseline hormonal parameters (anti-Müllerian hormone (AMH), cycle day-3 follicle-stimulating hormone, luteinizing hormone, and estradiol), and antral follicle count (AFC) were recorded. COS outcomes including the number of retrieved and metaphase II (MII) oocytes, follicular output index (FOI), and follicle-to-oocyte index (FORT) were documented. Fertilization was achieved via IVF or ICSI, and embryo transfer was performed on days 2–5.

resultsAMH levels were significantly lower in the MCL (21–28 days) group than in the MCL (29–35 days) group (p < 0.001). AFC levels were significantly lower in the MCL (21–28 days) group than in the MCL (29–35 days) group (p = 0.003). The number of oocytes developed after stimulation was significantly lower in the MCL (21–28 days) group than in the MCL (29–35 days) group (p < 0.001). The number of MII oocytes was significantly lower in the MCL (21–28 days) group than in the MCL (29–35 days) group (p < 0.001). The clinical pregnancy rate was significantly lower in the MCL (21–28 days) group than in the MCL (29–35 days) group (p = 0.017).

conclusionWithin the normal range of MCLs, longer cycles are associated with higher AMH and AFC levels and greater oocyte yields after controlled ovarian stimulation. Although women with longer cycles showed higher crude clinical pregnancy rates, MCL was not an independent predictor of clinical pregnancy once ovarian reserve markers were accounted for. These findings suggest that MCL is a simple, history-based indicator of underlying ovarian reserve and ovarian response.

Indexed as

Menstrual CycleOvarian ReserveOvulation InductionAdultAnti-Mullerian HormoneBiomarkersEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneHumansInfertility, FemaleLuteinizing HormoneOvarian FolliclePregnancyRetrospective StudiesAnti-Mullerian HormoneBiomarkersEstradiolFollicle Stimulating HormoneLuteinizing HormoneMenstrual cycle lengthOvarian reserveOvarian stimulation response

Identifiers

PMID41803788
PMCPMC12980889

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.