Evidence map›Paper›PMID 41804298›Full record

ArticleBrain and neuroscience advances

The LOAD2 mouse model of late-onset alzheimer's disease exhibits an accelerated onset of locomotor and anxiety deficits.

Shinwon Kang, Ashish Kadia, Junhui Wang, Rachael Ingram, Patrick Tidball, Fuzi Jin, Aram Abbasian, John Georgiou, Graham L Collingridge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and neuroscience advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shinwon KangDepartment of Physiology, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9461-3374
Ashish KadiaLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
Junhui WangLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
Rachael IngramLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
Patrick TidballLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-8983-1905
Fuzi JinLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
Aram AbbasianDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
John GeorgiouLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-4503-6384
Graham L CollingridgeDepartment of Physiology, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-onset alzheimer's disease is the most common form of dementia, and it arises from complex genetic and environmental interactions. Preclinical models that replicate the slow progression and long prodromal phase of late-onset alzheimer's disease are critical for identifying early therapeutic targets. The LOAD2 mouse model, developed on the C57BL/6J genetic background, integrates key late-onset alzheimer's disease genetic risk factors:

Indexed as

ageinganxietyLate-onset alzheimer’s diseaselearning and memorylocomotionprodromal symptoms

Identifiers

PMID41804298
PMCPMC12967343

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.