Exploring the link between glycated serum protein and esophageal metrics in diabetic GERD patients.

Objectives: This study assessed the relationship between glycated serum protein (GSP) and post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) in patients with diabetes mellitus (DM) with gastroesophageal reflux disease (GERD). Methods: General clinical data of patients in the DM and DM/GERD groups were compared. Multifactorial Logistic regression analyses were performed to screen for independent factors on GERD in DM patients, and odds ratio (OR) was calculated. The risk of GERD was assessed using a spline regression model constructed on the basis of GSP, PSPW and BI. Predictive efficacy was analyzed using Receiver operating curve (ROC) curve analysis. Results: Statistically significant differences were found in TG, hs-CRP, GSP, PSPW, and BI between patients in the DM and DM/GERD groups. PSPW and BI (OR=0.99, p<0.01) were independent protective factors, and elevated GSP was an independent risk factor for the development of GERD. A linear relationship was validated between GSP and PSPW and BI and the prevalence risk of developing GERD in patients with DM, all with good predictive efficacy. Conclusions: GSP, PSPW, and BI show significant correlations with the onset and progression of GERD in patients and all demonstrate good predictive efficacy. However, due to the small size of the patient cohort, the generalizability of these findings requires further validation.