ArticleHealth science reports2026
Insomnia-Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Insomnia-Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization.Health science reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Observational studies link insomnia to hippocampal atrophy, yet causal inference remains limited by confounding and reverse causality. While Mendelian randomization (MR) studies have explored sleep-brain associations, bidirectional causality between insomnia and hippocampal subfield volumes remains unaddressed. Methods: We conducted bidirectional two-sample MR using genome-wide association study (GWAS) summary data. Genetic instruments for insomnia ( Results: Forward MR revealed inverse associations between genetically proxied insomnia and six of eight hippocampal phenotypes: T1 left hippocampus volume (OR = 0.62, 95% CI = 0.43-0.89; Conclusions: Genetically proxied insomnia shows strong genetic evidence consistent with a causal reduction in hippocampal volumes. Clinically, early intervention in insomnia, particularly through cognitive-behavioral therapy for insomnia, may help preserve hippocampal health. This study highlights the importance of addressing insomnia as a public health priority. Future research should investigate the underlying biological mechanisms and incorporate more diverse cohorts to enhance the generalizability of these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.