Evidence map›Paper›PMID 41804500›Full record

ArticleHealth science reports2026

Diagnostic Value of Heparin-Binding Protein (HBP) in Pulmonary Infection After Radical Surgery for Lung Cancer: A Retrospective Study.

Yulan Wang, Lulu Guo, Bingjie Zeng, Yangyang Xu, Biao Xiang, Ziling Xia, Tianhuan Wang, Shihou Zheng, Changqiang Chen

Abstract read
In one paragraph

Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yulan WangDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID https://orcid.org/0000-0003-4448-2884
Lulu GuoDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Bingjie ZengDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Yangyang XuDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Biao XiangDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Ziling XiaDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Tianhuan WangDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Shihou ZhengDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Changqiang ChenDepartment of Clinical Laboratory Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID https://orcid.org/0009-0001-7558-8043

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Heparin-binding protein (HBP) has the potential clinical utility in the early diagnosis and prognosis evaluation of infectious diseases. We aimed to assess the early diagnostic value of HBP in combination with other biomarkers for detecting pulmonary infection post-surgery. Methods: We retrospectively included patients who underwent radical lung cancer surgery at the Shanghai Chest Hospital between January 2023 and August 2023. The least absolute shrinkage and selection operator (LASSO) and binary logistic regression analyses were conducted to identify independent predictors for pulmonary infection after surgery. The diagnostic performance of HBP and other biomarkers was assessed using the receiver operating characteristic (ROC) curves. Results: Among 292 patients, 31 (10.6%) developed pulmonary infection post-surgery, while 261 (89.4%) did not. The levels of HBP, white blood cell (WBC), neutrophil, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-8 (IL-8) were significantly higher in the pulmonary infection group compared to the control group ( Conclusion: HBP is an independent predictor of pulmonary infection following radical lung cancer surgery. Combined monitoring of HBP, NLR, and CRP can aid in the early diagnosis of postoperative pulmonary infections, supporting clinical assessment and timely intervention.

Indexed as

heparin‐binding proteininflammatory factorlung cancerpostoperative pulmonary infections

Identifiers

PMID41804500
PMCPMC12967616

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.