Evidence map›Paper›PMID 41804553›Full record

ArticleThe Permanente journal2026

Baseline Dementia Prevalence and Subtypes in Older Adults Hospitalized With Acute Coronary Syndrome: A Multicenter Study From a Large Integrated Health Care Delivery System.

Ashok Krishnaswami, Amanda Jain, Howard Dinh, Richard V Ha, Wynnelena C Canio, Michael G Nanna, Alicia Romero, Paola Gilsanz, Neelum T Aggarwal, Michelle M Mielke and 6 more

Abstract readMulticenter Study
In one paragraph

Article in The Permanente journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ashok KrishnaswamiThe Permanente Medical Group, Division of Cardiology, Kaiser Permanente San Jose Medical Center, San Jose, CA, USA.ORCID 0000-0002-7892-0726
Amanda JainKaiser Permanente, Division of Research, Pleasanton, CA, USA.
Howard DinhThe Permanente Medical Group, Department of Cardiology, Kaiser Permanente South Sacramento Medical Center, Sacramento, CA, USA.
Richard V HaThe Permanente Medical Group, Department of Cardiovascular Surgery, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA, USA.
Wynnelena C CanioThe Permanente Medical Group, Department of Geriatrics, Kaiser Permanente San Rafael Medical Center, San Rafael, CA, USA.
Michael G NannaSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Alicia RomeroThe Permanente Medical Group, Department of Cardiology, Kaiser Permanente San Francisco Medical Center, San Francisco, CA, USA.
Paola GilsanzKaiser Permanente, Division of Research, Pleasanton, CA, USA.
Neelum T AggarwalDepartment of Neurological Sciences, Rush Alzheimer's Disease Center, Chicago, IL, USA.
Michelle M MielkeDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mathew S MaurerDivision of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.
Janine Y YangDepartment of Internal Medicine, Kaiser Permanente, Santa Clara Medical Center, Santa Clara, CA, USA.
Edward Dong-Ho ShinDepartment of Internal Medicine, Kaiser Permanente, Oakland Medical Center, Oakland, CA, USA.ORCID 0009-0003-3380-9375
Divyesh M PatelThe Permanente Medical Group, Department of Anesthesiology and Critical Care, Kaiser Permanente, San Jose Medical Center, San Jose, CA, USA.
Abdulla A DamlujiCardiovascular Center on Aging, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Ahmed I ShahThe Permanente Medical Group, Department of Cardiology, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.

Funding

Frailty and Resiliency in Older Adults with Acute Myocardial InfarctionK23HL153771 · NHLBI · INOVA HEALTH CARE SERVICES · PI DAMLUJI, ABDULLA AL · 2020 to 2024
$916k
Estimating the treatment effect of cardiovascular medications to modify the risk for future cognitive decline in older adultsK76AG088428 · NIA · YALE UNIVERSITY · PI Michael Nanna · 2024 to 2026
$729k
NHLBI NIH HHS K23 HL153771NIA NIH HHS K76AG088428NIA NIH HHS P30-AG021334
6 · The paper itself

Abstract

backgroundDementia is increasingly common among older adults (≥ 65 years) and is associated with poor outcomes. However, little is known about its baseline prevalence in patients hospitalized with acute coronary syndrome (ACS), particularly across revascularization strategies.

methodsThe authors conducted a cross-sectional analysis from a current longitudinal cohort study of Kaiser Permanente Northern California members hospitalized with ACS between January 2010 and December 2020. Dementia diagnoses and subtypes were identified using International Classification of Diseases 9/10 codes. Baseline prevalence was compared across revascularization strategies: percutaneous coronary intervention, coronary artery bypass grafting, or no revascularization.

resultsAmong 26,749 patients with ACS, the mean age was 76.7 ± 8.0 years; patients not revascularized were older than those who were (77.7 ± 8.3 vs 74.9 ± 7.0 years;

conclusionOne in 17 older adults hospitalized with ACS had a documented diagnosis of dementia at baseline, with substantial variation by revascularization strategy. These findings highlight the baseline burden of dementia in this high-risk population and support the need for future research on the incidence and progression of cognitive impairment after ACS.

Indexed as

Acute Coronary SyndromeDementiaAgedAged, 80 and overCaliforniaCoronary Artery BypassCross-Sectional StudiesDelivery of Health Care, IntegratedFemaleHospitalizationHumansLongitudinal StudiesMalePercutaneous Coronary InterventionPrevalenceacute coronary syndromecognitive functioncoronary artery bypass graftingDementiapercutaneous coronary intervention

Identifiers

PMID41804553
PMCPMC13266666

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.